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Opaleye Management Inc. is named as a reporting person in SEC Form 4 filings. OQRO lists 154 transactions filed with the SEC under this name, the latest on Nov 6, 2026, each linked to the official Form 4.
Disclosures on record
154
Companies involved
6
64 buys, median +3.2 pts vs S&P 500, beat it 36 of 64 times.
Average +14.6 pts vs S&P 500. Each buy is one disclosure of open-market purchases in one company on one filing date, filed Oct 8, 2024 to Aug 4, 2026, measured from the first close after the filing. Past results, not a forecast.
Grace TherapeuticsGRCE
20 disclosures · Sep 2026 – Nov 2026 · 20 bought
Nov 3, 2026Bought~$18Kdisclosed Nov 6
DetailsOfficial recordNov 4, 2026Bought~$9.1Kdisclosed Nov 6
DetailsNov 5, 2026Bought~$5.5Kdisclosed Nov 6
DetailsOfficial recordOct 26, 2026Bought~$117K
DetailsOfficial recordOct 22, 2026Bought~$41Kdisclosed Oct 26
DetailsOfficial recordOct 19, 2026Bought~$8Kdisclosed Oct 21
DetailsOfficial recordOct 16, 2026Bought~$69Kdisclosed Oct 17
DetailsOfficial recordOct 15, 2026Bought~$46Kdisclosed Oct 17
DetailsOfficial recordOct 14, 2026Bought~$22Kdisclosed Oct 17
DetailsOfficial recordOct 9, 2026Bought~$11Kdisclosed Oct 13
DetailsOfficial recordOct 8, 2026Bought~$4.2Kdisclosed Oct 13
DetailsOfficial recordOct 12, 2026Bought~$15Kdisclosed Oct 13
DetailsOfficial recordOct 1, 2026Bought~$79Kdisclosed Oct 6
DetailsOfficial recordOct 2, 2026Bought~$41Kdisclosed Oct 6
DetailsOfficial recordOct 5, 2026Bought~$3.5Kdisclosed Oct 6
DetailsOfficial recordSep 21, 2026Bought~$21Kdisclosed Oct 2
DetailsOfficial recordSep 29, 2026Bought~$16Kdisclosed Oct 2
DetailsOfficial recordSep 23, 2026Bought~$11Kdisclosed Oct 2
DetailsOfficial recordSep 8, 2026Bought~$20Kdisclosed Sep 11
DetailsOfficial recordSep 9, 2026Bought~$12Kdisclosed Sep 11
DetailsOfficial recordAlpha CognitionACOG
58 disclosures · Feb 2026 – Oct 2026 · 58 bought
Oct 22, 2026Bought~$143Kdisclosed Oct 26
DetailsOfficial recordOct 23, 2026Bought~$123Kdisclosed Oct 26
DetailsOfficial recordOct 15, 2026Bought~$191Kdisclosed Oct 19
DetailsOfficial recordOct 16, 2026Bought~$118Kdisclosed Oct 19
DetailsOfficial recordOct 1, 2026Bought~$166Kdisclosed Oct 2
DetailsOfficial recordSep 24, 2026Bought~$157Kdisclosed Sep 28
DetailsOfficial recordSep 25, 2026Bought~$114Kdisclosed Sep 28
DetailsOfficial recordSep 16, 2026Bought~$455K
DetailsOfficial recordSep 14, 2026Bought~$351Kdisclosed Sep 16
DetailsOfficial recordSep 16, 2026Bought~$228K
DetailsOfficial recordSep 15, 2026Bought~$29Kdisclosed Sep 16
DetailsOfficial recordAug 3, 2026Bought~$400Kdisclosed Aug 4
DetailsOfficial recordJul 31, 2026Bought~$23Kdisclosed Aug 4
DetailsOfficial recordJul 24, 2026Bought~$1Kdisclosed Jul 28
DetailsOfficial recordJul 22, 2026Bought~$1.1Mdisclosed Jul 24
DetailsOfficial recordJul 23, 2026Bought~$389Kdisclosed Jul 24
DetailsOfficial recordJul 22, 2026Bought~$78Kdisclosed Jul 24
DetailsOfficial recordJun 26, 2026Bought~$975Kdisclosed Jun 29
DetailsOfficial recordJun 25, 2026Bought~$1.3Kdisclosed Jun 29
DetailsOfficial recordJun 15, 2026Bought~$27Kdisclosed Jun 16
DetailsOfficial recordJun 11, 2026Bought~$17Kdisclosed Jun 16
DetailsOfficial recordJun 12, 2026Bought~$1.6Kdisclosed Jun 16
DetailsOfficial recordJun 9, 2026Bought~$149Kdisclosed Jun 11
DetailsOfficial recordJun 10, 2026Bought~$35Kdisclosed Jun 11
DetailsOfficial recordJun 5, 2026Bought~$59Kdisclosed Jun 9
DetailsOfficial recordMay 29, 2026Bought~$416K
DetailsOfficial recordMay 28, 2026Bought~$12Kdisclosed May 29
DetailsOfficial recordMay 27, 2026Bought~$6.7Kdisclosed May 29
DetailsOfficial recordMay 21, 2026Bought~$91Kdisclosed May 22
DetailsOfficial recordMay 20, 2026Bought~$50Kdisclosed May 22
DetailsOfficial recordMay 18, 2026Bought~$99Kdisclosed May 19
DetailsOfficial recordMay 15, 2026Bought~$97Kdisclosed May 19
DetailsOfficial recordMar 27, 2026Bought~$51Kdisclosed Mar 31
DetailsOfficial recordMar 30, 2026Bought~$9.2Kdisclosed Mar 31
DetailsOfficial recordMar 25, 2026Bought~$47Kdisclosed Mar 26
DetailsOfficial recordMar 26, 2026Bought~$39K
DetailsOfficial recordMar 24, 2026Bought~$23Kdisclosed Mar 26
DetailsOfficial recordMar 18, 2026Bought~$14Kdisclosed Mar 20
DetailsOfficial recordMar 19, 2026Bought~$12Kdisclosed Mar 20
DetailsOfficial recordMar 16, 2026Bought~$7.7Kdisclosed Mar 18
DetailsOfficial recordMar 13, 2026Bought~$42K
DetailsOfficial recordMar 12, 2026Bought~$33Kdisclosed Mar 13
DetailsOfficial recordMar 9, 2026Bought~$13Kdisclosed Mar 10
DetailsOfficial recordMar 6, 2026Bought~$11Kdisclosed Mar 10
DetailsOfficial recordMar 5, 2026Bought~$244Kdisclosed Mar 6
DetailsOfficial recordMar 4, 2026Bought~$115Kdisclosed Mar 6
DetailsOfficial recordMar 5, 2026Bought~$29Kdisclosed Mar 6
DetailsOfficial recordMar 3, 2026Bought~$267Kdisclosed Mar 4
DetailsOfficial recordMar 2, 2026Bought~$116Kdisclosed Mar 4
DetailsOfficial recordMar 3, 2026Bought~$29Kdisclosed Mar 4
DetailsOfficial recordFeb 27, 2026Bought~$22Kdisclosed Mar 2
DetailsOfficial recordFeb 26, 2026Bought~$3.5Kdisclosed Mar 2
DetailsOfficial recordFeb 23, 2026Bought~$565Kdisclosed Feb 24
DetailsOfficial recordFeb 24, 2026Bought~$311K
DetailsOfficial recordFeb 24, 2026Bought~$29K
DetailsOfficial recordFeb 20, 2026Bought~$58Kdisclosed Feb 24
DetailsOfficial recordFeb 23, 2026Bought~$25Kdisclosed Feb 24
DetailsOfficial recordFeb 20, 2026Bought~$16Kdisclosed Feb 24
DetailsOfficial recordSanuwave HealthSNWV
19 disclosures · Nov 2024 – May 2026 · 11 sold · 8 bought
Apr 30, 2026Sold~$388Kdisclosed May 4
DetailsOfficial recordMay 1, 2026Sold~$162Kdisclosed May 4
DetailsOfficial recordApr 30, 2026Sold~$16Kdisclosed May 4
DetailsOfficial recordMay 1, 2026Sold~$8.1Kdisclosed May 4
DetailsOfficial recordApr 28, 2026Sold~$809Kdisclosed Apr 30
DetailsOfficial recordApr 29, 2026Sold~$403Kdisclosed Apr 30
DetailsOfficial recordApr 28, 2026Sold~$46Kdisclosed Apr 30
DetailsOfficial recordApr 29, 2026Sold~$17Kdisclosed Apr 30
DetailsOfficial recordApr 17, 2026Sold~$231Kdisclosed Apr 21
DetailsOfficial recordApr 17, 2026Sold~$102Kdisclosed Apr 21
DetailsOfficial recordApr 21, 2026Sold~$4.1K
DetailsOfficial recordOct 6, 2025Bought~$38Kdisclosed Oct 9
DetailsOfficial recordApr 29, 2025Bought~$76Kdisclosed Apr 30
DetailsOfficial recordApr 29, 2025Bought~$127Kdisclosed Apr 30
DetailsOfficial recordNov 1, 2024Bought~$122K
DetailsOfficial recordNov 1, 2024Bought~$122K
DetailsOfficial recordOct 31, 2024Bought~$96Kdisclosed Nov 1
DetailsOfficial recordOct 30, 2024Bought~$35Kdisclosed Nov 1
DetailsOfficial recordOct 31, 2024Bought~$65Kdisclosed Nov 1
DetailsOfficial recordCodexisCDXS
37 disclosures · Oct 2024 – Aug 2025 · 37 bought
Jul 31, 2025Bought~$226Kdisclosed Aug 4
DetailsOfficial recordAug 4, 2025Bought~$2.2K
DetailsOfficial recordJul 29, 2025Bought~$24Kdisclosed Jul 31
DetailsOfficial recordJul 30, 2025Bought~$4.4Kdisclosed Jul 31
DetailsOfficial recordJul 18, 2025Bought~$282Kdisclosed Jul 22
DetailsOfficial recordJun 27, 2025Bought~$239Kdisclosed Jul 1
DetailsOfficial recordJun 12, 2025Bought~$225Kdisclosed Jun 16
DetailsOfficial recordJun 13, 2025Bought~$221Kdisclosed Jun 16
DetailsOfficial recordJun 16, 2025Bought~$114K
DetailsOfficial recordMay 23, 2025Bought~$5.48Mdisclosed May 28
DetailsOfficial recordMay 28, 2025Bought~$12K
DetailsOfficial recordApr 30, 2025Bought~$58Kdisclosed May 2
DetailsOfficial recordMay 1, 2025Bought~$46Kdisclosed May 2
DetailsOfficial recordApr 25, 2025Bought~$56Kdisclosed Apr 29
DetailsOfficial recordApr 16, 2025Bought~$149Kdisclosed Apr 17
DetailsOfficial recordApr 17, 2025Bought~$94K
DetailsOfficial recordApr 15, 2025Bought~$56Kdisclosed Apr 17
DetailsOfficial recordApr 8, 2025Bought~$198Kdisclosed Apr 9
DetailsOfficial recordApr 3, 2025Bought~$173K
DetailsOfficial recordApr 1, 2025Bought~$87Kdisclosed Apr 3
DetailsOfficial recordApr 2, 2025Bought~$12Kdisclosed Apr 3
DetailsOfficial recordMar 21, 2025Bought~$236Kdisclosed Mar 24
DetailsOfficial recordMar 20, 2025Bought~$18disclosed Mar 24
DetailsOfficial recordMar 13, 2025Bought~$216Kdisclosed Mar 14
DetailsOfficial recordMar 6, 2025Bought~$261Kdisclosed Mar 10
DetailsOfficial recordMar 4, 2025Bought~$145Kdisclosed Mar 6
DetailsOfficial recordMar 5, 2025Bought~$27Kdisclosed Mar 6
DetailsOfficial recordFeb 28, 2025Bought~$441Kdisclosed Mar 4
DetailsOfficial recordMar 3, 2025Bought~$133Kdisclosed Mar 4
DetailsOfficial recordFeb 10, 2025Bought~$94Kdisclosed Feb 13
DetailsOfficial recordFeb 12, 2025Bought~$60Kdisclosed Feb 13
DetailsOfficial recordFeb 11, 2025Bought~$51Kdisclosed Feb 13
DetailsOfficial recordJan 31, 2025Bought~$193Kdisclosed Feb 1
DetailsOfficial recordJan 30, 2025Bought~$90Kdisclosed Feb 1
DetailsOfficial recordDec 30, 2024Bought~$164Kdisclosed Jan 2
DetailsOfficial recordDec 31, 2024Bought~$47Kdisclosed Jan 2
DetailsOfficial recordOct 25, 2024Bought~$73Kdisclosed Oct 28
DetailsOfficial recordEton PharmaceuticalsETON
9 disclosures · Oct 2024 – Jun 2025 · 9 bought
Jun 10, 2025Bought~$79Kdisclosed Jun 12
DetailsOfficial recordJun 10, 2025Bought~$46Kdisclosed Jun 12
DetailsOfficial recordOct 23, 2024Bought~$80Kdisclosed Oct 25
DetailsOfficial recordOct 4, 2024Bought~$102Kdisclosed Oct 8
DetailsOfficial recordOct 8, 2024Bought~$211K
DetailsOfficial recordOct 7, 2024Bought~$72Kdisclosed Oct 8
DetailsOfficial recordOct 8, 2024Bought~$28K
DetailsOfficial recordOct 4, 2024Bought~$13Kdisclosed Oct 8
DetailsOfficial recordOct 7, 2024Bought~$9Kdisclosed Oct 8
DetailsOfficial recordHarrowHROW
11 disclosures · Jan 2025 – Jun 2025 · 11 sold
Jun 9, 2025Sold~$462Kdisclosed Jun 11
DetailsOfficial recordJun 10, 2025Sold~$462Kdisclosed Jun 11
DetailsOfficial recordJun 3, 2025Sold~$90Kdisclosed Jun 5
DetailsOfficial recordJun 4, 2025Sold~$54Kdisclosed Jun 5
DetailsOfficial recordMay 12, 2025Sold~$259Kdisclosed May 14
DetailsOfficial recordMar 24, 2025Sold~$150Kdisclosed May 14
DetailsOfficial recordMar 18, 2025Sold~$148Kdisclosed May 14
DetailsOfficial recordMay 13, 2025Sold~$133Kdisclosed May 14
DetailsOfficial recordMar 18, 2025Sold~$150Kdisclosed Mar 26
DetailsOfficial recordFeb 28, 2025Sold~$140Kdisclosed Mar 4
DetailsOfficial recordJan 22, 2025Sold~$712Kdisclosed Jan 25
DetailsOfficial recordAs of the latest filing on , Opaleye Management Inc. reported holding 2,855,000 shares of Eton Pharmaceuticals (ETON), worth about $183M at the last close of $64 (Nov 13, 2026), held through a managed account, an opaleye, l.p. Holdings are also on file at Sol-Gel Technologies (SLGL), Alpha Cognition (ACOG), Codexis (CDXS), Grace Therapeutics (GRCE), Harrow (HROW), Sanuwave Health (SNWV); together they are worth about $263M. In the last 12 months, Opaleye Management Inc. bought $8.8M in 78 open-market purchases and sold $2.19M in 11 sales.
| Company | Shares reported | How held | Last close | Value at last close | Reported |
|---|---|---|---|---|---|
| Eton Pharmaceuticals ETON | 2,855,000 | 85K managed account · 2.77M opaleye, l.p | $64 | $183M | Jun 10, 2025 |
| Sol-Gel Technologies SLGL | 555,000 | 540K opaleye, l.p · 15K managed account | $55 | $30.6M | Sep 11, 2026 |
| Alpha Cognition ACOG | 3,391,984 | 3.29M opaleye, l.p · 100K managed account | $8 | $28.2M | Oct 23, 2026 |
| Codexis CDXS | 10,134,989 | 180K managed account · 9.96M opaleye, l.p | $1 | $11.8M | Dec 1, 2025 |
| Grace Therapeutics GRCE | 3,054,853 | 3.05M opaleye, l.p | $2 | $5.53M | Nov 5, 2026 |
| Harrow HROW | 90,000 | 90K managed account | $30 | $2.71M | Jun 10, 2025 |
| Sanuwave Health SNWV | 858,569 | 5,000 managed account · 854K opaleye, l.p | $2 | $1.56M | May 1, 2026 |
Is this Opaleye Management Inc.’s net worth? No. A Form 4 reports the shares an insider owns in one company after each transaction, directly or through trusts and entities. It says nothing about cash, other investments, property or debt, options not yet exercised are not counted here, and a holding reported some time ago may have changed without a new filing. The value is shares times the last stored close, not a price anyone received. Sources: the filings listed below, each linked to EDGAR. Compare with the biggest insider stakes.
On the latest SEC Form 4, dated Jun 10, 2025, Opaleye Management Inc. reported holding 2,855,000 shares of Eton Pharmaceuticals (ETON), held indirectly. At the last close of $64 on Nov 13, 2026, that is about $183M. This is the stake disclosed in filings, not a net worth.
In SEC filings of the last 12 months, Opaleye Management Inc. reported 11 open-market sales worth $2.19M and 78 open-market purchases worth $8.8M. Shares withheld for taxes, gifts and option exercises are not counted in these totals.
Opaleye Management Inc. bought shares on the open market in 10 different years since 2015 across 9 companies. Sales in each of the last 3 years.
In SEC filings since 2015: the latest open-market purchase is from 2026; the latest open-market sale is from 2026.
9 companies: Alpha Cognition (ACOG, 2026), Grace Therapeutics (GRCE, 2026), Sanuwave Health (SNWV, 2024–2026), Harrow (HROW, 2015–2025), Eton Pharmaceuticals (ETON, 2020–2025) and others.
Opaleye Management Inc. bought shares on the open market in 10 different years since 2015 across 9 companies. Sales in each of the last 3 years.
Opaleye Management Inc. reported 278 open-market purchases and 93 sales since 2015; purchases in 10 different years, most recently 2026.
| Year | Bought | Sold |
|---|---|---|
| 2026 | $8.8M78×78 trades | $2.19M11×11 trades |
| 2025 | $10.1M39×39 trades | $2.76M11×11 trades |
| 2024 |
$7.34M32×32 trades |
$1.75M36×36 trades |
| 2023 | $493K3×3 trades | — |
| 2022 | $9.18M56×56 trades | $42K2×2 trades |
| 2021 | $2.45M34×34 trades | $10.1M33×33 trades |
| 2020 | $11.1M30×30 trades | — |
| 2019 | $79K2×2 trades | — |
| 2016 | $326K2×2 trades | — |
| 2015 | $299K2×2 trades | — |
Open-market purchases (code P) and sales (code S) on Forms 4 and 5. Up to Sep 2024 from the SEC's Insider Transactions Data Sets; since Oct 2024 from each filing as it is published. A trade filed twice (an amendment) counts once. Dollar totals use the price the filer reported; lines with no price count as trades without a value.
Opaleye Management Inc. reported 63 open-market purchases and 11 sales here, 2015 to 2025.
Opaleye Management Inc. reported 31 open-market purchases and 38 sales here, 2020 to 2024.
Opaleye Management Inc. reported 58 open-market purchases and 0 sales here, 2026.
Closing prices and the companies' last annual figures; a − or + is a fact of the close, not a forecast.
