Opaleye Management reported an Alpha Cognition share purchase

What did Opaleye Management report?

The SEC Form 4 identifies Opaleye Management Inc. as a 10% owner and reports an open-market purchase of 22,657 Alpha Cognition (ACOG) shares at $8.43 each. The reported purchase value was about $191K.

The transaction date was Oct 15, 2026, and the Form 4 was filed on Oct 19, 2026, 4 days later. The filing states that the shares are held indirectly. It reports a post-purchase holding of 3,245,611 shares, an increase of about 0.7% over the estimated holding before the transaction.

How does this purchase compare with other filings?

In the 365 days to Oct 19, 2026, OQRO holds 71 other open-market purchases by this person, about $8.17M in total. 55 of those purchases were at Alpha Cognition. OQRO also holds 11 open-market sales by this person in that period, about $2.19M in total. The previous open-market purchase by this person on record at OQRO was 0 months earlier.

At Alpha Cognition, 15 other open-market purchases, about $3.7M by 2 insiders, were filed in the 90 days to Oct 19, 2026. In the 365 days before that, 44 were filed, about $4.56M in total, an average of 10.8 per 90 days. These comparisons use only the filings OQRO holds.

The largest other filing of the same kind in that period was by Robert James Wills, Director, about $96K on Aug 24, 2026.

What other ownership records are on file?

FINRA reported short interest for ACOG of 323,405 shares on the settlement date of Sep 30, 2026, +54.57% on the previous report, or about 2.79 days of average volume.

In 13F filings for the quarter ended Mar 31, 2026, the largest position that grew was Cable Car Capital, LP, which increased its position to 322,127 shares. No largest position that shrank was on record. A 13F is a quarter-end snapshot and does not include a trade date.

What was recorded around the transaction date?

Press coverage listed by Finnhub included Yahoo, Oct 13, 2026, with the headline “Alpha Cognition Announces Publication of U.S. Patent Application Relating to Proprietary Manufacturing Process for ZUNVEYL®.” The headline is listed as published by the outlet; OQRO has not checked it or summarized the article.

ACOG closed at $8.45 on Oct 15, 2026, the last session on or before the trade date. From Sep 15, 2026 to Oct 15, 2026, the close moved from $8.80 to $8.45, a change of −4.0%. From Oct 15, 2026 to Oct 19, 2026, the close moved from $8.45 to $8.50, a change of +0.6%. For company filing context, see Alpha Cognition on OQRO.

What this does not tell you?

A Form 4 reports a transaction; it does not say why it was made. As general background, many companies let insiders trade only in a window that opens after results, and a sale can also follow an option exercise, a tax bill or a pre-arranged plan. This Form 4 does not say which of these applies here. OQRO notes a plan only when a filing footnote says so.

The filing does not explain the share-price moves, and other news can move a price. The comparisons use only the filings OQRO holds. This describes public filings and is not investment advice.